Isolation and Genomic Analyses of an Early SARS-CoV-2 Strains from the 2020 Epidemic in Gwangju, South Korea

Min Ji Kim; Ji-eun Lee; Tae sun Kim; Jungwook Park; Mi hyeon Lim; Da jeong Hwang; Jin Jeong; Kwang gon Kim; Ji-eun Yoon; Hye young Kee; Jong-jin Park; Jin jong Seo; Jae Keun Chung

doi:10.4167/jbv.2021.51.3.138

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2021 Vol.51, Issue 3 Preview Page

Original Article

Isolation and Genomic Analyses of an Early SARS-CoV-2 Strains from the 2020 Epidemic in Gwangju, South Korea

30 September 2021. pp. 138-147

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Abstract

Since the first identification of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in China in late December 2019, the coronavirus disease 2019 (COVID-19) has spread fast around the world. RNA viruses, including SARS-CoV-2, have higher gene mutations than DNA viruses during virus replication. Variations in SARS-CoV-2 genome could contribute to efficiency of viral spread and severity of COVID-19. In this study, we analyzed the locations of genomic mutations to investigate the genetic diversity among isolates of SARS-CoV-2 in Gwangju. We detected non-synonymous and frameshift mutations in various parts of SARS-CoV-2 genome. The phylogenetic analysis for whole genome showed that SARS-CoV-2 genomes in Gwangju isolates are clustered within clade V and G. Our findings not only provide a glimpse into changes of prevalent virus clades in Gwangju, South Korea, but also support genomic surveillance of SARS-CoV-2 to aid in the development of efficient therapeutic antibodies and vaccines against COVID-19.

Keywords

SARS-COV-2

Whole-genome sequencing

Genomic mutation

Gwangju

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Information

Publisher :The Korean Society for Microbiology and The Korean Society of Virology
Publisher(Ko) :대한미생물학회‧대한바이러스학회
Journal Title :JOURNAL OF BACTERIOLOGY AND VIROLOGY
Volume : 51
No :3
Pages :138-147
Received Date : 2021-08-04
Revised Date : 2021-09-15
Accepted Date : 2021-09-16
DOI :https://doi.org/10.4167/jbv.2021.51.3.138

JOURNAL OF BACTERIOLOGY AND VIROLOGYISSN:1598-2467(Print) 2093-0429(Online)대한미생물학회‧대한바이러스학회

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