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2020 Vol.50, Issue 4

Review Article

The Roles of Chemokines in Immune Response to Mycobacterial Infection
Seungwha Paik12
,
Miso Yang12
,
Hyun-Woo Suh12
,
Eun-Kyeong Jo12†
1Department of Microbiology, Chungnam National University School of Medicine
2Infection Control Convergence Research Center, Chungnam National University School of Medicine
*hayoungj@cnu.ac.kr
31 December 2020. pp. 203-217
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Abstract

Tuberculosis (TB), a global and deadly infectious disease caused by Mycobacterium tuberculosis (Mtb), is manifested with host immune reaction. The balanced regulation between protective immune and pathologic inflammatory responses is critical to control progression to TB. Chemokines are a large family of cytokines that play an essential role for chemotaxis of immune and inflammatory cells to the sites of infection. Numerous chemokines including CXCL10 were reported as potential biomarkers of various stages of TB infection. In addition, several chemokines and their receptors play as key players to coordinate host immune defense as innate effectors and mediators of adaptive immune responses. Accumulating evidence suggests that some chemokines, if uncontrolled, are associated with host pathological inflammation during infection. In this review, we will discuss recent advances in understanding which chemokines have potentials as diagnostic markers. In addition, we focus the roles and mechanisms by which chemokines and their receptors are involved in both host immune protection and pathology during TB infection. The controlled activation of chemokine system will determine the coordinated biological outcomes of innate immune responses during pathogenic infection.

Keywords
Tuberculosis
Chemokine
Biomarker
Immune response
Inflammation
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Information
  • Publisher :The Korean Society for Microbiology and The Korean Society of Virology
  • Publisher(Ko) :대한미생물학회‧대한바이러스학회
  • Journal Title :JOURNAL OF BACTERIOLOGY AND VIROLOGY
  • Volume : 50
  • No :4
  • Pages :203-217
  • Received Date : 2020-11-18
  • Revised Date : 2020-12-10
  • Accepted Date : 2020-12-14
  • DOI :https://doi.org/10.4167/jbv.2020.50.4.203
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