Survey on Hepatitis B virus and Hepatitis C Virus Coinfection in the Human Immunodeficiency Virus-infected Patients

Hye-Yeoun Lee; So-Hyun Lee; Woon-Ho Kim; Mi-Young Seo; Hak-Hyun Kim; Ji-Hye Park

doi:10.4167/jbv.2022.52.3.115

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Original Article

Survey on Hepatitis B virus and Hepatitis C Virus Coinfection in the Human Immunodeficiency Virus-infected Patients

30 September 2022. pp. 115-119

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Abstract

Human immunodeficiency virus (HIV), a blood-borne viral disease, weakens the immune system and causes opportunistic infections or cancers, which can eventually lead to Acquired Immune Deficiency Syndrome (AIDS). Generally antiretroviral therapy (ART) in HIV infected patients reduces morbidity and mortality, but also increases the risk of liver disease in patients coinfected with Hepatitis B virus (HBV) or Hepatitis C virus (HCV), previously known as the leading cause of death from HIV infection. In this study, HIV positive-sera were investigated seroprevalence of HBV and HCV which were requested for HIV test from 2020 to 2021. Of the total 232 samples, there are 184 cases (79.1%) in hospital, 33 cases (14.2%) in public health center, 6 cases (2.6%) in correctional institution and 2 cases (0.9%) in the military manpower administration. Hepatitis B virus surface antigen (HBsAg) was detected in 13 cases (5.6%) and hepatitis C virus antibody (anti-HCV) in 16 cases (6.9%) and also both in 4 cases (1.7%) of 232 samples. The results of HBsAg and hepatitis B virus core antibody (anti-HBc) for 107 samples were anti-HBc positive in 36 cases (35.6%) and HBsAg positive in 4 cases (1.7%). The results confirmed that coinfection with HBV and HCV was more common in HIV infected people than in the general population in Korea. These findings from this study were provided as fundamental data for HIV infection prevention and ART therapy selection.

Keywords

HIV

Hepatitis B virus

Hepatitis C virus

Coinfection

References

World Health Organization. HIV/AIDS. [https://www.who.int/news-room/fact-sheets/detail/hiv-aids]

Choi JH, Kim SN, Park P, Cho KS. Global HIV/AIDS Statistics. PHWR 2017;10:1298-303.[https://nih.go.kr/board/board.es?mid=a20602010000&bid=0034&list_no=77090&act=view#]

Korea Disease Control and Prevention Agency. Annual report on the Notified HIV/AIDS in Korea 2020. Chungju-si, Republic Korea: Korea Disease control and Prevention Agency; 2020. p.14-17. [https://www.kdca.go.kr/npt/biz/npp/portal/nppPblctDtaView.do?pblctDtaSeAt=1&pblctDtaSn=2431]

Buchacz K, Baker RK, Palella FJ Jr, Chmiel JS, Lichtenstein KA, Novak RM, et al. AIDS-defining opportunistic illnesses in US patients, 1994-2007: a cohort study. AIDS 2010;24:1549-59.

10.1097/QAD.0b013e32833a396720502317

Schwarcz L, Chen MJ, Vittinghoff E, Hsu L, Schwarcz S. Declining incidence of AIDS-defining opportunistic illnesses: results from 16 years of population-based AIDS surveillance. AIDS 2013;27:597-605.

10.1097/QAD.0b013e32835b0fa223079812

Kim MJ, Chang HH, Kim SI, Kim YJ, Park DW, Kang C, et al. Trend of CD4+ cell counts at diagnosis and initiation of highly active antiretroviral therapy (HAART): Korea HIV/AIDS Cohort Study, 1992-2015. Infect Chemother 2017;49:101-8.

10.3947/ic.2017.49.2.10128608664PMC5500264

Alter MJ. Epidemiology of viral hepatitis and HIV co-infection. J Hepatol 2005;44:6-9.

10.1016/j.jhep.2005.11.00416352363

Rockstroh JK. Influence of viral hepatitis on HIV infection. J Hepatol 2006;44:S6-9.

10.1016/j.jhep.2005.11.00416352363

Kim YC, Ahn JY, Kim JM, Kim YJ, Park DW, Yoon YK, et al. Human Immunodeficiency Virus (HIV) and Hepatitis Virus Coinfection among HIV-infected Korean Patients: The Korea HIV/AIDS Cohort Study. Infect Chemother 2017;49:268-74.

10.3947/ic.2017.49.4.26829299894PMC5754337

Lincoln D, Petoumenos K, Dore GJ. HIV/HBV and HIV/HCV coinfection, and outcomes following highly active antiretroviral therapy. HIV med 2003;4:241-9.

10.1046/j.1468-1293.2003.00152.x12859323

Dodig M, Tavill AS. Hepatitis C and Human immunodeficiency virus coinfections. J Clin Gastroenterol 2001;33:367-74.

10.1097/00004836-200111000-0000511606851

Tien PC. Management and treatment of hepatitis C virus infection in HIV-infected adults: recommendations from the Veterans Affairs Hepatitis C Resource Center Program and National Hepatitis C program Office. Am J Gastroenterol 2005;100:2338-54.

10.1111/j.1572-0241.2005.00222.x16181388

Mohammadi M, Talei G, Sheikhian A, Ebrahimzade F, Pournia Y, Ghasemi E, et al. Survey of both hepatitis B virus (HBsAg) and hepatitis C virus (HCV-Ab) coinfection among HIV postivie patients. Virol J 2009;6:202.

10.1186/1743-422X-6-20219922624PMC2785785

Lee S, Lee SH, Lee SJ, Kim KH, Lee JE, Cho H, et al. Incidence and risk factors of hepatitis C virus infection among human immunodeficiency virus (HIV) patients in a large HIV clinic in South Korea. Korean J intern Med 2016;31:772-8.

10.3904/kjim.2015.35327117318PMC4939506

Lee HH, Hong HG, Son JS, Kwon SM, Lim BG, Lee KB, et al. Prevalence of Hepatitis B virus and HIV co-infection in Korea. J Bacteriol Virol 2016;46:283-7.

10.4167/jbv.2016.46.4.283

Korea Disease Control and Prevention Agency. Infectious disease portal. [http://www.kdca.go.kr/npt/][https://www.kdca.go.kr/npt/biz/npp/ist/simple/simplePdStatsMain.do][https://www.kdca.go.kr/npt/biz/npp/ist/simple/simplePdStatsMain.do]

Information

Publisher :The Korean Society for Microbiology and The Korean Society of Virology
Publisher(Ko) :대한미생물학회‧대한바이러스학회
Journal Title :JOURNAL OF BACTERIOLOGY AND VIROLOGY
Volume : 52
No :3
Pages :115-119
Received Date : 2022-07-27
Revised Date : 2022-09-27
Accepted Date : 2022-09-28
DOI :https://doi.org/10.4167/jbv.2022.52.3.115

JOURNAL OF BACTERIOLOGY AND VIROLOGY ISSN:1598-2467(Print) 2093-0429(Online)

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