Trends in Norovirus Distribution among the Children of Childcare Center

Eun-Seon Hur; Il-Hyung Jeong; Sun-Mok Kwon; Min-Sung Kang; So-Jung Park; Yoon-Hee Lee; Hui-Su Pyeon; Bum-Ho Kim; Yong-Bae Park

doi:10.4167/jbv.2023.53.1.011

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2023 Vol.53, Issue 1 Preview Page Next Page

Original Article

Trends in Norovirus Distribution among the Children of Childcare Center

30 June 2023. pp. 11-18

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Abstract

Noroviruses are pathogens as being the leading cause of acute gastroenteritis (AGE) across all age groups, especially among vulnerable population, less than 5 years old. This study examined a total of 994 specimens collected from 58 cases of the kindergartens populations in Gyeonggi-Do from 2019 to 2021 to estimate the incidence of viral enteropathogens and analyze molecular genetic characteristics. Noroviruses were the most common viral pathogen causing among these population with acute gastroenteritis (n=55, 94.8% of cases tested). We found that norovirus outbreak of kindergarten exhibited a seasonality from the winter to summer with a peak in April. In particular, genotype GII noroviruses were particularly prevalent in the kindergarten population, with GII-4/2012 being highly detected in 119 specimens, followed by GII-3 and GII-2 as pathogenic agents causing AGE. Samples from workers or environment (toilet, doorknob, toy) were positive for a same genetic norovirus (GII-4/2012). Our results suggest that special attention needs to be paid to any possible contamination with noroviruses. Furthermore, a regular monitoring system can help prevent the norovirus outbreaks.

Keywords

Norovirus

Outbreak

Kindergarten

Genotype

References

Ahmed SM, Hall AJ, Robinson AE, Verhoef L, Premkumar P, Parashar UD, et al. Global prevalence of norovirus in cases of gastroenteritis: a systematic review and meta-analysis. Lancet Infect Dis 2014;14:725-30. 10.1016/S1473-3099(14)70767-424981041

Nguyen GT, Phan K, Teng I, Pu J, Watanabe T. A systematic review and meta-analysis of the prevalence of norovirus in cases of gastroenteritis in developing countries. Medicine 2017;96:e8139. 10.1097/MD.000000000000813928984764PMC5738000

Cannon JL, Lopman BA, Payne DC, Vinjé J. Birth cohort studies assessing norovirus infection and immunity in young children: a review. Clin Infect Dis 2019;69:357-65. 10.1093/cid/ciy98530753367PMC7962893

Chhabra P, Rouhani S, Browne H, Peñataro Yori P, Siguas Salas M, Paredes Olortegui M, et al. Homotypic and heterotypic protection and risk of re-infection following natural norovirus infection in a highly endemic setting. Clin Infect Dis 2021;72:222-9. 10.1093/cid/ciaa01933501947PMC7840104

Shioda K, Kambhampati A, Hall AJ, Lopman BA. Global age distribution of pediatric norovirus cases. Vaccine 2015;33:4065-8. 10.1016/j.vaccine.2015.05.05126051514PMC4612353

Morillo SG, Timenetsky Mdo C. Norovirus: an overview. Rev Assoc Med Bras 2011;57:453-8. 10.1016/S0104-4230(11)70094-X21876931

Teunis PF, Moe CL, Liu P, Miller SE, Lindesmith L, Baric RS, et al. Norwalk virus: how infectious is it? J Med Virol 2008;80:1468-76. 10.1002/jmv.2123718551613

Moore MD, Goulter RM, Jaykus LA. Human Norovirus as a Foodborne Pathogen: Challenges and Developments. Annu Rev Food Sci Technol 2015;6:411-33. 10.1146/annurev-food-022814-01564325884284

Marks PJ, Vipond IB, Carlisle D, Deakin D, Fey RE, Caul EO. Evidence for airborne transmission of Norwalk-like virus (NLV) in a hotel restaurant. Epidemiol Infect 2000;124:481-7. 10.1017/S095026889900380510982072PMC2810934

Kroneman A, Vega E, Vennema H, Vinjé J, White PA, Hansman G, et al. Proposal for a unified norovirus nomenclature and genotyping. Arch Virol 2013;158:2059-68. 10.1007/s00705-013-1708-523615870PMC5570552

Thorne LG, Goodfellow IG. Norovirus gene expression and replication. J Gen Virol 2014;95:278-91. 10.1099/vir.0.059634-024243731

Chhabra P, de Graaf M, Parra GI, Chan MC, Green K, Martella V, et al. Updated classification of norovirus genogroups and genotypes. J Gen Virol 2019;100:1393-406. 10.1099/jgv.0.00131831483239PMC7011714

Bok K, Abente EJ, Realpe-Quintero M, Mitra T, Sosnovtsev SV, Kapikian AZ, et al. Evolutionary dynamics of GII.4 noroviruses over a 34-year period. J Virol 2009;83:11890-901. 10.1128/JVI.00864-0919759138PMC2772697

Hoa Tran TN, Trainor E, Nakagomi T, Cunliffe NA, Nakagomi O. Molecular epidemiology of noroviruses associated with acute sporadic gastroenteritis in children: global distribution of genogroups, genotypes and GII.4 variants. J Clin Virol 2013;56:185-93. 10.1016/j.jcv.2012.11.01123218993

Eden JS, Hewitt J, Lim KL, Boni MF, Merif J, Greening G, et al. The emergence and evolution of the novel epidemic norovirus GII.4 variant Sydney 2012. Virology 2014;450-451:106-13. 10.1016/j.virol.2013.12.00524503072PMC3984403

Cannon JL, Bonifacio J, Bucardo F, Buesa J, Bruggink L, Chan MC, et al. Global Trends in Norovirus Genotype Distribution among Children with Acute Gastroenteritis. Emerg Infect Dis 2021;27:1438-45. 10.3201/eid2705.20475633900173PMC8084493

Eden JS, Tanaka MM, Boni MF, Rawlinson WD, White PA. Recombination within the pandemic norovirus GII.4 lineage. J Virol 2013;87:6270-82. 10.1128/JVI.03464-1223536665PMC3648122

Boon D, Mahar JE, Abente EJ, Kirkwood CD, Purcell RH, Kapikian AZ, et al. Comparative evolution of GII.3 and GII.4 norovirus over a 31-year period. J Virol 2011;85:8656-66. 10.1128/JVI.00472-1121715504PMC3165818

Mans J. Norovirus infections and disease in lower-middle and low-income countries, 1997-2018. Viruses 2019;11:341. 10.3390/v1104034130974898PMC6521228

Sakon N, Yamazaki K, Nakata K, Kanbayashi D, Yoda T, Mantani M, et al. Impact of genotype-specific herd immunity on the circulatory dynamism of norovirus: a 10-year longitudinal study of viral acute gastroenteritis. J Infect Dis 2015;211:879-88. 10.1093/infdis/jiu49625210139

Ruis C, Lindesmith LC, Mallory ML, Brewer-Jensen PD, Bryant JM, Costantini V, et al. Preadaptation of pandemic GII.4 noroviruses in unsampled virus reservoirs years before emergence. Virus Evol 2020;6:veaa067. 10.1093/ve/veaa06733381305PMC7751145

Information

Publisher :The Korean Society for Microbiology and The Korean Society of Virology
Publisher(Ko) :대한미생물학회‧대한바이러스학회
Journal Title :JOURNAL OF BACTERIOLOGY AND VIROLOGY
Volume : 53
No :1
Pages :11-18
Received Date : 2023-06-14
Revised Date : 2023-06-20
Accepted Date : 2023-06-22
DOI :https://doi.org/10.4167/jbv.2023.53.1.011

JOURNAL OF BACTERIOLOGY AND VIROLOGY ISSN:1598-2467(Print) 2093-0429(Online)

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