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2025 Vol.55, Issue 3 Preview Page

Review Article

The Role of Autophagy during Nontuberculous Mycobacterial Infection
Young Jae Kim12
,
Asmita Sapkota1
,
Bomi Lee123
,
Eun-Jin Park123
,
Eun-Kyeong Jo12*
1Department of Microbiology, College of Medicine, Chungnam National University, Daejeon 35015, Republic of Korea
2Department of Medical Science, College of Medicine, Chungnam National University, Daejeon 35015, Republic of Korea
3Brain Korea 21 FOUR Project for Medical Science, College of Medicine, Chungnam National University, Daejeon 35015, Republic of Korea
*hayoungj@cnu.ac.kr
30 September 2025. pp. 205-221
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Abstract

Nontuberculous mycobacteria (NTM)—including Mycobacterium abscessus and M. avium complex—are emerging as major causes of pulmonary diseases worldwide. Treatment is hindered by the intrinsic resistance of most NTM to many antibiotics. Developing novel therapeutics, therefore, requires a better understanding of the host defense mechanisms against NTM. Autophagy is a lysosome- dependent pathway that degrades large macromolecular aggregates, damaged organelles, and intracellular pathogens. However, compared with M. tuberculosis, a major pathogen for human tuberculosis, the role of autophagy in NTM infection is far less well elucidated. This review explores the current understanding of autophagy-mediated host autophagy responses affecting NTM pathogenesis and intracellular homeostasis, as well as highlights several candidate agents that stimulate host autophagy and lysosomal activity to combat NTM infections. Elucidating these mechanisms could facilitate the development of more effective therapeutics for these increasingly prevalent infections.

Keywords
Autophagy
Nontuberculous mycobacteria
Xenophagy
Mycobacteria
Therapeutics
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  • Publisher :The Korean Society for Microbiology and The Korean Society of Virology
  • Publisher(Ko) :대한미생물학회‧대한바이러스학회
  • Journal Title :JOURNAL OF BACTERIOLOGY AND VIROLOGY
  • Volume : 55
  • No :3
  • Pages :205-221
  • Received Date : 2025-07-07
  • Revised Date : 2025-09-02
  • Accepted Date : 2025-09-08
  • DOI :https://doi.org/10.4167/jbv.2025.55.3.205
Journal Informaiton JOURNAL OF BACTERIOLOGY AND VIROLOGY JOURNAL OF BACTERIOLOGY AND VIROLOGY
  • NRF
  • 임플란트학회 전용 배너
  • KOFST
  • crossref crossmark
  • crossref cited-by
  • crossref funder-registry
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  • orcid
  • open access
  • ccl
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