Study on the Distribution of Carbapenem-Resistant Enterobacteriaceae (CRE) in Busan,  2022

Kyeong-A Kim; Hye-sook Heo; Hye-jun Kim; Su-jin Shin; Young-ran Na

doi:10.4167/jbv.2023.53.2.119

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2023 Vol.53, Issue 2 Preview Page Next Page

Original Article

Study on the Distribution of Carbapenem-Resistant Enterobacteriaceae (CRE) in Busan, 2022

31 December 2023. pp. 119-130

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Abstract

This study was conducted on the incidence of as carbapenemase-resistant Enterobacteriaceae (CRE) infection and carbapenemase-producing Enterobacteriaceae (CPE) gene distribution in Busan to prepare basic data for preventing the spread of CRE infection by confirming the regional characteristics of CRE infection. The total of 2,429 strains from 92 clinics were obtained from rectal swab, sputum, stool, urine, blood, wound, bile, transtracheal aspiration, pus, ascetic fluid, bronchial washing, catheter tip, genital, skin, sore, tissue, from January to December 2022. The CRE infection was tested by the method tested by the Korea Disease Control and Prevention Agency (KDCA). Species identification was confirmed by VITEK 2. Klebsiella pneumoniae which was detected in 1,698 (70.2%), was the most common isolated CRE, followed by Escherichia coli in 430 (17.8%), Enterobacter cloacae 90 (3.7%) and Citrobacter freundii 44 (1.8%). Among the identified CREs, 2,029 (83.5%) strains were identified as CPE. More than half of the detected CPE types were 1,680 (69.2%) of KPC-2 (Klebsiella pneumonia carbapenases-2), followed by 166 (6.8%) of NDM-1 (New Delhi metallo-β-lactamase-1), 58 (2.4%) of KPC-3, and 51 (2.4%) of NDM-5. These findings provide good basic data for comprehensive surveillance of CREs, suggesting that KPC and NDM are widespread in Busan. In the analyzed CRE samples, Ertapenem resistance was the most common at 99.5%, imipenem resistance 72.3%, meropenem resistance 67.9%, and doripenem resistance 48.7%. It is expected that this study can be used as basic data for preparing suitable countermeasures against CRE infection in the community in the future.

Keywords

Carbapenem-resistant Enterobacteriaceae (CRE)

Carbapenem-producing Enterobacteriaceae (CPE)

Carbapenem

Klebsiella pneumoniae

Klebsiella pneumonia carbapenemase (KPC)

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Information

Publisher :The Korean Society for Microbiology and The Korean Society of Virology
Publisher(Ko) :대한미생물학회‧대한바이러스학회
Journal Title :JOURNAL OF BACTERIOLOGY AND VIROLOGY
Volume : 53
No :2
Pages :119-130
Received Date : 2023-08-30
Revised Date : 2023-09-21
Accepted Date : 2023-10-23
DOI :https://doi.org/10.4167/jbv.2023.53.2.119

JOURNAL OF BACTERIOLOGY AND VIROLOGY ISSN:1598-2467(Print) 2093-0429(Online)

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