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2021 Vol.51, Issue 4

Review Article

Beneficial Therapy with Natural Anti-Inflammatory Agents and Supplements
Fatema Akhter1
Mohammad Saydur Rahman1
G M Al Amin2
Md. Ibrahim Miah3
Young-Sang Koh4*
1Department of Pharmacy, Jagannath University, Dhaka-1100, Bangladesh
2Department of Botany, Jagannath University, Dhaka-1100, Bangladesh
3Department of Microbiology, University of Dhaka, Dhaka-1000, Bangladesh
4Department of Microbiology and Immunology, College of Medicine, and Jeju Research Center for Natural Medicine, Jeju National University, Jeju 63243, Republic of Korea
*yskoh7@jejunu.ac.kr
31 December 2021. pp. 149-162
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Abstract

Inflammation is a protective mechanism against injury or tissue damage. Depending on the extent of inflammation, various disease conditions can be induced. The incidence of inflammatory diseases has increased in recent years; synthetic nonsteroidal anti-inflammatory drugs (NSAIDs) and steroids are usually used to treat this condition. Synthetic NSAIDs cause side effects; thus, natural medicines may be effective alternatives. Many natural anti-inflammatory agents and supplements are currently available, including natural anti-inflammatory polysaccharides, green tea, curcumin, colchicine, stingless bee honey, capsaicin, monoterpene kaempferol, omega-3 fatty acids, certain vitamins, minerals, and others. The mechanisms of action of these natural anti-inflammatory agents and supplements are very similar to those of synthetic anti-inflammatory agents, exhibiting anti-inflammatory activity mainly through inhibiting actions of pro-inflammatory cytokines including interleukins, tumor necrosis factor-α (TNF-α), and chemokines. In addition, some natural anti- inflammatory agents inhibit the action of cyclooxygenase enzymes (mainly COX2), inducible nitric oxide (iNOS), reactive oxygen species (ROS), and nuclear factor- kappa B (NF-κB) signaling molecules. Although the effectiveness of these natural anti-inflammatory agents and supplements is similar to that of chemical NSAIDs and steroids, they are safer to use. The purpose of this review is to summarize existing research data and discuss the activity of natural anti-inflammatory agents and supplements.

Keywords
Inflammation
NSAIDS
Anti-inflammatory agents
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Information
  • Publisher :The Korean Society for Microbiology
  • Publisher(Ko) :대한미생물학회
  • Journal Title :JOURNAL OF BACTERIOLOGY AND VIROLOGY
  • Volume : 51
  • No :4
  • Pages :149-162
  • Received Date :2021. 08. 27
  • Revised Date :2021. 12. 12
  • Accepted Date : 2021. 12. 14
  • DOI :https://doi.org/10.4167/jbv.2021.51.4.149
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