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2022 Vol.52, Issue 1 Preview Page

Original Article

Genetic Distribution of Carbapenem-Resistant Enterobacteriaceae in Seoul Korea, 2018~2020
Sang-Hun Park1†
,
So-Hyun Park1
,
Jin-Seok Kim1
,
Jin-Kyung Yu1
,
Jin-Kyoung Kim1
,
Hyo-Sun Suh1
,
Eun Young Kwon1
,
Kyoung Ae Park1
,
Eui Kyung Cha1
,
Jae Min Shin1
,
Hyo-Won Jeoung1
,
Su-Jin Jeon1
,
Young-Ok Hwang1
,
Jib-Ho Lee1
,
Yong-Seoung Shin1
1Seoul Metropolitan Government Research Institute of Public Health and Environment, 30, Janggunmaeul 3-gil, Gwacheon-si, Gyeonggi-do 13818, Republic of Korea
*sanghun93@seoul.go.kr
31 March 2022. pp. 28-38
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Abstract

The present study was carried out to describe the prevalence and characteristics of CPEs among the CRE strains isolated from adult and children patients. A total of 8,147 clinical isolates were obtained from blood, urine, stool, sputum, lesion, bile, pus, tracheal aspiration, and etc., hospitals from 2018 to 2020. Species identification was confirmed by Bruker Biotyper MALDI-TOF MS (Bruker Daltonics GmbH, Bremen, Germany) and VITEK 2 (bioMérieux, Marcy l'Etoile, France). K. pneumoniae, which was detected in 4,690 (58.9%), was the most common isolated CRE, followed by Escherichia coli (E. coli) (detected in 1,747 [20.8%]), Enterobacter cloacae complex (502 [6.0%]), Citrobacter koseri (265 [3.1%]), Klebsiella aerogenes (254 [3.0%]), and Citrobacter freundii (220 [2.6%]). More than half of the detected CPE types were KPC-2 (58.6%), followed by NDM-1 (7.4%), NDM-5 (3.4%). Co-existence of NDM-5 and OXA-181 was detected in E. coli (60/63, 95.2%) followed by K. pneumoniae (3/63, 4.8%). These findings provide good basic data for comprehensive surveillance of CREs suggesting that KPC Klebsiella pneumoniae carbapenemases (Klebsiella pneumoniae carbapenemases) and NDM (New Delhi metallo-β-lactamase) are widespread in Seoul, Korea.

Keywords
Carbapenem-resistant enterobacteriaceae (CRE)
Carbapenemase-producing enterobacteriaceae (CPE)
Klebsiella pneumoniae
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Information
  • Publisher :The Korean Society for Microbiology and The Korean Society of Virology
  • Publisher(Ko) :대한미생물학회‧대한바이러스학회
  • Journal Title :JOURNAL OF BACTERIOLOGY AND VIROLOGY
  • Volume : 52
  • No :1
  • Pages :28-38
  • Received Date : 2021-12-31
  • Revised Date : 2022-03-30
  • Accepted Date : 2022-03-30
  • DOI :https://doi.org/10.4167/jbv.2022.52.1.028
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