Seroprevalence of Severe Fever with Thrombocytopenia Syndrome Virus in Mui Island,  Rural Area,  Incheon,  South Korea

Myung Deok Kim-Jeon; Song Mi Moon; Sung Suck Oh; Haeyoung Kim; Yeon-Ja Koh; Seung Jegal; Se Youn Han; Mi Yeon Lee; Young Woo Gong; Yoon Soo Park

doi:10.4167/jbv.2022.52.2.064

All Issue

2022 Vol.52, Issue 2 Preview Page Next Page

Original Article

Seroprevalence of Severe Fever with Thrombocytopenia Syndrome Virus in Mui Island, Rural Area, Incheon, South Korea

30 June 2022. pp. 64-71

PDF XML

Abstract

The rural areas are the main outbreak sites of severe fever with thrombocytopenia syndrome (SFTS). To identify the seroprevelance of SFTS in rural island, we conducted a serosurveillance study of SFTS virus (SFTSV) of the general public in Mui Island, a representative rural island of Incheon, South Korea. A total of 203 participants (female 127, male 76, 30 to 97 years old, median 67) without symptoms or signs of SFTS were collected via a convenience sampling. Nested reverse transcription PCR was conducted for both the S and M segments of SFTSV gene. Indirect immunofluorescence assay was also performed for immunoglobulin G (IgG) and immunoglobulin M (IgM) against SFTSV. Only 1 participant (0.5%) was positive to SFTSV gene without IgM against SFTSV. In addition, 12 participants (5.9%) were positive to IgG against SFTSV. Seropositive rate of IgG against SFTSV was higher in age group >65 than ≤65 (9.6% vs. 1.1%, OR 9.202; 95% CI, 1.165–72.692; p=0.026) and was not statistically significant according to sex, occupation and duration of residence in Mui Island. This study suggests that SFTSV readily have infected humans in the rural island of Incheon, South Korea. Therefore, reinforced surveillance about SFTS is needed, focusing on medically vulnerable area such as an island.

Keywords

Severe fever with thrombocytopenia syndrome

Seroprevalence

Rural island

References

Yu XJ, Liang MF, Zhang SY, Liu Y, Li JD, Sun YL, et al. Fever with thrombocytopenia associated with a novel bunyavirus in China. N Engl J Med 2011;364:1523-32.

10.1056/NEJMoa101009521410387PMC3113718

Casel MA, Park SJ, Choi YK. Severe fever with thrombocytopenia syndrome virus: emerging novel phlebovirus and their control strategy. Exp Mol Med 2021;53:713-22.

10.1038/s12276-021-00610-133953322PMC8178303

Liu Q, He B, Huang SY, Wei F, Zhu XQ. Severe fever with thrombocytopenia syndrome, an emerging tick-borne zoonosis. Lancet Infect Dis 2014;14:763-72.

10.1016/S1473-3099(14)70718-2

Kim KH, Yi J, Kim G, Choi SJ, Jun KI, Kim NH, et al. Severe fever with thrombocytopenia syndrome, South Korea, 2012. Emerg Infect Dis 2013;19:1892-4.

10.3201/eid1911.13079224206586PMC3837670

Takahashi T, Maeda K, Suzuki T, Ishido A, Shigeoka T, Tominaga T, et al. The first identification and retrospective study of Severe Fever with Thrombocytopenia Syndrome in Japan. J Infect Dis 2014;209:816-27.

10.1093/infdis/jit60324231186PMC7107388

Tran XC, Yun Y, Van An L, Kim SH, Thao NTP, Man PKC, et al. Endemic Severe Fever with Thrombocytopenia Syndrome, Vietnam. Emerg Infect Dis 2019;25:1029-31.

10.3201/eid2505.18146331002059PMC6478219

Lin TL, Ou SC, Maeda K, Shimoda H, Chan JP, Tu WC, et al. The first discovery of severe fever with thrombocytopenia syndrome virus in Taiwan. Emerg Microbes Infect 2020;9:148-51.

10.1080/22221751.2019.171043631918622PMC6968498

Song BJ, Lim HC, Jeon DY, Song HJ. Distribution and Detection of Severe Fever with Thrombocytopenia Syndrome Virus in Ticks Collected from Jeollanam-do, Korea. J Bacteriol Virol 2016;46:93-8.

10.4167/jbv.2016.46.2.93

Lee KH, Medlock JM, Heo ST. Severe Fever with Thrombocytopenia Syndrome Virus, Crimean-Congo Haemorrhagic Fever Virus, and Migratory Birds. J Bacteriol Virol 2013;43:235-43.

10.4167/jbv.2013.43.4.235

Agency KDCP. Infectious Diseases Surveillance Yearbook, 2020. (https://www.kdca.go.kr/npt/biz/npp/portal/nppPblct DtaView.do?pblctDtaSeAt=1&pblctDtaSn=2452.)

Kim KH, Ko MK, Kim N, Kim HH, Yi J. Seroprevalence of Severe Fever with Thrombocytopenia Syndrome in Southeastern Korea, 2015. J Korean Med Sci 2017;32:29-32.

10.3346/jkms.2017.32.1.2927914128PMC5143294

Yoo JR, Heo ST, Kim M, Song SW, Boo JW, Lee KH. Seroprevalence of Severe Fever with Thrombocytopenia Syndrome in the Agricultural Population of Jeju Island, Korea, 2015-2017. Infect Chemother 2019;51:337-44.

10.3947/ic.2019.51.4.33731668024PMC6940373

Han MA, Kim CM, Kim DM, Yun NR, Park SW, Han MG, et al. Seroprevalence of Severe Fever with Thrombocytopenia Syndrome Virus Antibodies in Rural Areas, South Korea. Emerg Infect Dis 2018;24:872-4.

10.3201/eid2405.15210429664384PMC5938763

Ding S, Niu G, Xu X, Li J, Zhang X, Yin H, et al. Age is a critical risk factor for severe fever with thrombocytopenia syndrome. PLoS One 2014;9:e111736.

10.1371/journal.pone.011173625369237PMC4219771

Zhang L, Ye L, Ojcius DM, Lou X, Wang C, feng C, et al. Characterization of severe fever with thrombocytopenia syndrome in rural regions of Zhejiang, China. PLoS One 2014;9:e111127.

10.1371/journal.pone.011112725356556PMC4214719

Sun JM, Zhang YJ, Gong ZY, Zhang L, Lv HK, Lin JF, et al. Seroprevalence of severe fever with thrombocytopenia syndrome virus in southeastern China and analysis of risk factors. Epidemiol Infect 2015;143:851-6.

10.1017/S095026881400131924866248PMC4411641

Huang X, Zhang Z, Jin G, Wang X, Tan C, Yin H, et al. Presence of Antibodies against Severe Fever with Thrombocytopenia Syndrome Virus in Non-Endemic Areas of China. Jpn J Infect Dis 2017;70:248-51.

10.7883/yoken.JJID.2016.21427580581

Im JH, Baek J, Durey A, Kwon HY, Chung MH, Lee JS. Current Status of Tick-Borne Diseases in South Korea. Vector Borne Zoonotic Dis 2019;19:225-33.

10.1089/vbz.2018.229830328790

Li Z, Hu J, Bao C, Li P, Qi X, Qin Y, et al. Seroprevalence of antibodies against SFTS virus infection in farmers and animals, Jiangsu, China. J Clin Virol 2014;60:185-9.

10.1016/j.jcv.2014.03.02024793967

Ding F, Guan XH, Kang K, Ding SJ, Huang LY, Xing XS, et al. Risk factors for bunyavirus-associated severe Fever with thrombocytopenia syndrome, china. PLoS Negl Trop Dis 2014;8:e3267.

10.1371/journal.pntd.000326725330383PMC4199554

Cho SS, Lee TK, Bang YW, Kim CJ, Im HJ, Kwon YJ, et al. Factors Associated with Unmet Needs for Medical Care among Island Inhabitants in Korea. J Agric Med Community Health 2010;35:151-64.

10.5393/JAMCH.2010.35.2.151

Yu SH, Cho WH, Park CY, Lee MK. Health Care Utilization and Its Determinants among Island Inhabitants. J Prev Med Pubic Health 1987;20:287-300.

Park SW, Han MG, Yun SM, Park C, Lee WJ, Ryou J. Severe fever with thrombocytopenia syndrome virus, South Korea, 2013. Emerg Infect Dis 2014;20:1880-2.

10.3201/eid2011.14088825341085PMC4214315

Li P, Tong ZD, Li KF, Tang A, Dai YX, Yan JB. Seroprevalence of severe fever with thrombocytopenia syndrome virus in China: A systematic review and meta-analysis. PloS one 2017;12:e0175592.

10.1371/journal.pone.017559228399161PMC5388504

Zeng P, Ma L, Gao Z, Wang J, Liu J, Huang X, et al. A study of seroprevalence and rates of asymptomatic viremia of severe fever with thrombocytopenia syndrome virus among Chinese blood donors. Transfusion 2015;55:965-71.

10.1111/trf.1295325496479PMC4428969

Niu G, Li J, Liang M, Jiang X, Jiang M, Yin H, et al. Severe fever with thrombocytopenia syndrome virus among domesticated animals, China. Emerg Infect Dis 2013;19:756-63.

10.3201/eid1905.12024523648209PMC3647489

Information

Publisher :The Korean Society for Microbiology and The Korean Society of Virology
Publisher(Ko) :대한미생물학회‧대한바이러스학회
Journal Title :JOURNAL OF BACTERIOLOGY AND VIROLOGY
Volume : 52
No :2
Pages :64-71
Received Date : 2022-06-07
Revised Date : 2022-06-26
Accepted Date : 2022-06-27
DOI :https://doi.org/10.4167/jbv.2022.52.2.064

JOURNAL OF BACTERIOLOGY AND VIROLOGY ISSN:1598-2467(Print) 2093-0429(Online)

All Issue