Molecular Epidemiological Study of Measles Cases in Gyeonggi Province

Baek-Sang Han, Su-Kyong Moon, Sin-Hee Park, Kyong-Shin Ryu, Eun-Bee Kim

doi:10.4167/jbv.2022.52.4.137

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2022 Vol.52, Issue 4 Next Page

Original Article

Molecular Epidemiological Study of Measles Cases in Gyeonggi Province

31 December 2022. pp. 137-144

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Abstract

Measles is one of the highly contagious infectious diseases in which about 90% of the groups that have no immunity against measles are infected when exposed to the measles virus. Even after the Republic of Korea was certified as a ‘national measles eradication’ by the WHO in March 2014, two import-related outbreaks of measles occurred in 2014 and 2019. In this study, we analyzed epidemiological characteristics and genetic distribution of measles cases. Ninety-eight nasopharyngeal or oropharyngeal swab samples that confirmed cases of measles in Gyeonggi province in 2019 were conducted genotyping assay and sequence analysis. Fifty cases were classified as group outbreak-related cases and Forty-eight cases were classified as sporadic cases. As a result of genetic analysis, these cases were classified into D8, B3, and A genotypes, and except for the A type which was known as the vaccine type, D8 and B3 types were identified as import-related measles viruses. As with these results, for the complete eradication of measles, not only a high-quality surveillance system but also molecular epidemiological analysis data must be supported. The results of this study are expected to be used as important data for establishing a quarantine system through the accumulation of measles virus genotyping data and case reports data in the future when measles occurs in South Korea.

Keywords

Measles virus

Molecular epidemiology

Genotype

Sequence analysis

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Information

Publisher :The Korean Society for Microbiology
Publisher(Ko) :대한미생물학회
Journal Title :JOURNAL OF BACTERIOLOGY AND VIROLOGY
Volume : 52
No :4
Pages :137-144
Received Date :2022. 08. 26
Revised Date :2022. 10. 31
Accepted Date : 2022. 12. 12
DOI :https://doi.org/10.4167/jbv.2022.52.4.137

JOURNAL OF BACTERIOLOGY AND VIROLOGY ISSN:1598-2467(Print) 2093-0429(Online)

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