Molecular Epidemiological Study of Measles Cases in Gyeonggi Province

Baek-Sang Han; Su-Kyong Moon; Sin-Hee Park; Kyong-Shin Ryu; Eun-Bee Kim

doi:10.4167/jbv.2022.52.4.137

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2022 Vol.52, Issue 4 Next Page

Original Article

Molecular Epidemiological Study of Measles Cases in Gyeonggi Province

31 December 2022. pp. 137-144

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Abstract

Measles is one of the highly contagious infectious diseases in which about 90% of the groups that have no immunity against measles are infected when exposed to the measles virus. Even after the Republic of Korea was certified as a ‘national measles eradication’ by the WHO in March 2014, two import-related outbreaks of measles occurred in 2014 and 2019. In this study, we analyzed epidemiological characteristics and genetic distribution of measles cases. Ninety-eight nasopharyngeal or oropharyngeal swab samples that confirmed cases of measles in Gyeonggi province in 2019 were conducted genotyping assay and sequence analysis. Fifty cases were classified as group outbreak-related cases and Forty-eight cases were classified as sporadic cases. As a result of genetic analysis, these cases were classified into D8, B3, and A genotypes, and except for the A type which was known as the vaccine type, D8 and B3 types were identified as import-related measles viruses. As with these results, for the complete eradication of measles, not only a high-quality surveillance system but also molecular epidemiological analysis data must be supported. The results of this study are expected to be used as important data for establishing a quarantine system through the accumulation of measles virus genotyping data and case reports data in the future when measles occurs in South Korea.

Keywords

Measles virus

Molecular epidemiology

Genotype

Sequence analysis

References

Coughlin MM, Beck AS, Bankamp B, Rota PA. Perspective on Global Measles Epidemiology and Control and the Role of Novel Vaccination Strategies. Viruses 2017;9:11. 10.3390/v901001128106841PMC5294980

Zhang Y, Ji Y, Jiang X, Xu S, Zhu Z, Zheng L, et al. Genetic characterization of measles viruses in China, 2004. Virol J 2008;5:120. 10.1186/1743-422X-5-12018928575PMC2600640

Getahun M, Beyene B, Ademe A, Teshome B, Tefera M, Asha A, et al. Epidemiology of laboratory confirmed measles virus cases in Amhara Regional State of Ethiopia, 2004-2014. BMC Infect Dis 2016;16:133. 10.1186/s12879-016-1457-727001744PMC4802717

Ludlow M, McQuaid S, Milner D, de Swart RL, Duprex WP. Pathological consequences of systemic measles virus infection. J Pathol 2015;235:253-65. 10.1002/path.445725294240

Ferren M, Horvat B, Mathieu C. Measles Encephalitis: Towards New Therapeutics. Viruses 2019;11:1017. 10.3390/v1111101731684034PMC6893791

Patel MK, Goodson JL, Alexander JP Jr, Kretsinger K, Sodha SV, Steulet C, et al. Progress Toward Regional Measles Elimination - Worldwide, 2000-2019. MMWR Morb Mortal Wkly Rep 2020;69:1700-05. 10.15585/mmwr.mm6945a633180759PMC7660667

Beaty SM, Lee B. Constraints on the Genetic and Antigenic Variability of Measles Virus. Viruses 2016;8:109. 10.3390/v804010927110809PMC4848602

Aref S, Bailey K, Fielding A. Measles to the Rescue: A Review of Oncolytic Measles Virus. Viruses 2016;8:294. 10.3390/v810029427782084PMC5086626

Moss WJ, Griffin DE. Global measles elimination. Nat Rev Microbiol 2006;4:900-8. 10.1038/nrmicro155017088933PMC7097605

Bellini WJ, Rota PA. Genetic diversity of wild-type measles viruses: implications for global measles elimination programs. Emerg Infect Dis 1998;4:29-35. 10.3201/eid0401.9801059452396PMC2627654

Xu W, Tamin A, Rota JS, Zhang L, Bellini WJ, Rota PA. New genetic group of measles virus isolated in the People's Republic of China. Virus Res 1998;54:147-56. 10.1016/S0168-1702(98)00020-39696123

Chibo D, Riddell M, Catton M, Birch C. Novel measles virus genotype, East Timor and Australia. Emerg Infect Dis 2002;8:735-7. 10.3201/eid0807.01040912095446PMC2730329

Center for Disease Control and Prevention. Genetic Analysis of Measles Viruses. [URL]: https://www.cdc.gov/measles/ lab-tools/genetic-analysis.html

Griffin DE. Measles Vaccine. Viral Immunol 2018;31:86-95. 10.1089/vim.2017.014329256824PMC5863094

Conis E. Measles and the Modern History of Vaccination. Public Health Rep 2019;134:118-25. 10.1177/003335491982655830763141PMC6410476

Gay NJ. The theory of measles elimination: implications for the design of elimination strategies. J Infect Dis 2004;189:S27-35. 10.1086/38159215106086

World Health Organization. Guidelines on Verification of Measles and Rubella Elimination in the Western Pacific Region, second edition, 2019.

Russell SJ, Babovic-Vuksanovic D, Bexon A, Cattaneo R, Dingli D, Dispenzieri A, et al. Oncolytic Measles Virotherapy and Opposition to Measles Vaccination. Mayo Clin Proc 2019;94:1834-39. 10.1016/j.mayocp.2019.05.00631235278PMC6800178

Kim YC, Choi YH. Current and Prospect on Measles Outbreak. Korean J Med 2019;94:237-45. 10.3904/kjm.2019.94.3.237

Korea Disease Control and Prevention Agency, Infectious Disease Portal, [URL]: https://www.kdca.go.kr/npt/biz/ npp/ist/bass/bassDissStatsMain.do

Yun HJ, Park PH, Hwang SI, Huh JW, Nam SJ, Yong KC, et al. Molecular epidemiological study of measles virus throughout an imported epidemic outbreak in Gyeonggi-do in 2014. Korean J Microbiol 2017;53:1-8. 10.7845/kjm.2017.6061

Lengyel G, Marossy A, Ánosi N, Farkas SL, Kele B, Nemes-Nikodém É, et al. Screening of more than 2000 Hungarian healthcare workers' anti-measles antibody level: results and possible population-level consequences. Epidemiol Infect 2018;147:e7. 10.1017/S095026881800257130201057PMC6518749

Seok H, Park DW, Kim KN, KIM MJ, Kim SH, Kim JY, et al. Report of the Korean Society of Infectious Diseases Roundtable Discussion on Responses to the Measles Outbreaks in Korea in 2019. Infect Chemother 2021 Sep;53:405-20. 10.3947/ic.2021.008434623775PMC8511360

World Health Organization. Global progress against measles threatened amidst COVID-19 pandemic. 2021; [URL]: https://www.who.int/news/item/10-11-2021-global-progress-against-measles-threatened-amidst-covid-19-pandemic

Korea Disease Control and Prevention Agency. National Childhood Vaccination Coverage Among Children Aged 1-3 and 6 years in Korea, 2020. 2021;11-1352159-000856-10.

Information

Publisher :The Korean Society for Microbiology
Publisher(Ko) :대한미생물학회
Journal Title :JOURNAL OF BACTERIOLOGY AND VIROLOGY
Volume : 52
No :4
Pages :137-144
Received Date : 2022-08-26
Revised Date : 2022-10-31
Accepted Date : 2022-12-12
DOI :https://doi.org/10.4167/jbv.2022.52.4.137

JOURNAL OF BACTERIOLOGY AND VIROLOGY ISSN:1598-2467(Print) 2093-0429(Online)

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