All Issue

2025 Vol.55, Issue 4

Review Article

Diagnostic Biomarker Candidate Discovery using Metabolomics of the Latent Mycobacterium tuberculosis
Jae Jin Lee1
,
Young Jae Kim234
,
Eun-jin Park23
,
Keun Choi1
,
Hyungjin Eoh15*
1Department of Immunology and Immune Therapeutics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
2Department of Microbiology, College of Medicine, Chungnam National University, Daejeon 35015, Republic of Korea
3Department of Medical Science, College of Medicine, Chungnam National University, Daejeon 35015, Republic of Korea
4Brain Korea 21 FOUR Project for Medical Science, College of Medicine, Chungnam National University, Daejeon 35015, Republic of Korea
5Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
*heoh@usc.edu
31 December 2025. pp. 281-297
PDF XML Citation
Abstract

Tuberculosis (TB) remains a global public health crisis, responsible for approximately 1.3 million deaths annually. The effectiveness of current chemotherapy is limited by its inability to eradicate persister populations of Mycobacterium tuberculosis (Mtb), a minor fraction of phenotypic variants that exhibit high tolerance to TB antibiotics. Although the mechanisms underlying persister formation are not fully understood, accumulating evidence indicates that intermittent antibiotic exposure and innate immune pressures amplify persister formation, underscoring the importance of persister-specific adaptive metabolism. Mtb persisters arise through remodeling of central carbon and nitrogen metabolism, enabling survival under bactericidal oxidative stresses and facilitating entry into a latent TB infection state. This review summarizes recent advances in understanding the metabolic strategies employed by Mtb persisters to enhance intrinsic antibiotic tolerance and establish latent TB infection. The findings highlight metabolomics as a powerful tool for identifying previously unexplored metabolic signatures of Mtb persisters and for screening potential diagnostic biomarkers of persisters and drug-resistant TB.

Keywords
Tuberculosis
Metabolomics
Central Carbon Metabolism
Diagnistic Biomarkers
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Information
  • Publisher :The Korean Society for Microbiology and The Korean Society of Virology
  • Publisher(Ko) :대한미생물학회‧대한바이러스학회
  • Journal Title :JOURNAL OF BACTERIOLOGY AND VIROLOGY
  • Volume : 55
  • No :4
  • Pages :281-297
  • Received Date : 2025-12-13
  • Revised Date : 2025-12-23
  • Accepted Date : 2025-12-25
  • DOI :https://doi.org/10.4167/jbv.2025.55.4.281
Journal Informaiton JOURNAL OF BACTERIOLOGY AND VIROLOGY JOURNAL OF BACTERIOLOGY AND VIROLOGY
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