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2025 Vol.55, Issue 4 Preview Page

Original Article

31 December 2025. pp. 327-340
Abstract
References
1

Effah CY, Sun T, Liu S, Wu Y. Klebsiella pneumoniae: an increasing threat to public health. Ann Clin Microbiol Antimicrob. 2020;19(1):1.

10.1186/s12941-019-0343-831918737PMC7050612
2

Choby JE, Howard-Anderson J, Weiss DS. Hypervirulent Klebsiella pneumoniae - clinical and molecular perspectives. J Intern Med. 2020;287(3):283–300.

10.1111/joim.1300731677303PMC7057273
3

Russo TA, Olson R, Fang CT, Stoesser N, Miller M, MacDonald U, et al. Identification of Biomarkers for Differentiation of Hypervirulent Klebsiella pneumoniae from Classical K. pneumoniae. J Clin Microbiol. 2018;56(9):e00776-18.

10.1128/JCM.00776-1829925642PMC6113484
4

Lin ZW, Zheng JX, Bai B, Xu GJ, Lin FJ, Chen Z, et al. Characteristics of Hypervirulent Klebsiella pneumoniae: Does Low Expression of rmpA Contribute to the Absence of Hypervirulence? Front Microbiol. 2020;11:436.

10.3389/fmicb.2020.0043632256482PMC7090111
5

Yu WL, Ko WC, Cheng KC, Lee HC, Ke DS, Lee CC, et al. Association between rmpA and magA genes and clinical syndromes caused by Klebsiella pneumoniae in Taiwan. Clin Infect Dis. 2006;42(10):1351–1358.

10.1086/503420
6

Unverdorben LV, Pirani A, Gontjes K, Moricz B, Holmes CL, Snitkin ES, et al. Klebsiella pneumoniae evolution in the gut leads to spontaneous capsule loss and decreased virulence potential. mBio. 2025;16(5):e0236224.

10.1128/mbio.02362-2440162782PMC12077207
7

Arredondo-Alonso S, Blundell-Hunter G, Fu Z, Gladstone RA, Fillol-Salom A, Loraine J, et al. Evolutionary and functional history of the Escherichia coli K1 capsule. Nat Commun. 2023;14(1):3294.

10.1038/s41467-023-39052-w37322051PMC10272209
8

Teng G, Qin Q, Ding S, Wu Y, Fu Y, Zhang M, et al. The wzc mutation mediates virulence changes in K1-type Klebsiella pneumoniae within the same patient. Front Microbiol. 2025;16:1577629.

10.3389/fmicb.2025.157762940444005PMC12119577
9

Bachman MA, Breen P, Deornellas V, Mu Q, Zhao L, Wu W, et al. Genome-Wide Identification of Klebsiella pneumoniae Fitness Genes during Lung Infection. mBio. 2015;6(3):e00775.

10.1128/mBio.00775-1526060277PMC4462621
10

Dashti AA, Jadaon MM, Abdulsamad AM, Dashti HM. Heat Treatment of Bacteria: A Simple Method of DNA Extraction for Molecular Techniques. Kuwait Medical Journal. 2009;41(2):117–122.

11

Fang CT, Chuang YP, Shun CT, Chang SC, Wang JT. A novel virulence gene in Klebsiella pneumoniae strains causing primary liver abscess and septic metastatic complications. J Exp Med. 2004;199(5):697–705.

10.1084/jem.2003085714993253PMC2213305
12

Compain F, Babosan A, Brisse S, Genel N, Audo J, Ailloud F, et al. Multiplex PCR for detection of seven virulence factors and K1/K2 capsular serotypes of Klebsiella pneumoniae. J Clin Microbiol. 2014;52(12):4377–4380.

10.1128/JCM.02316-1425275000PMC4313302
13

Yu WL, Fung CP, Ko WC, Cheng KC, Lee CC, Chuang YC. Polymerase chain reaction analysis for detecting capsule serotypes K1 and K2 of Klebsiella pneumoniae causing abscesses of the liver and other sites. J Infect Dis. 2007;195(8):1235–1236.

10.1086/512686
14

Yu F, Lv J, Niu S, Du H, Tang YW, Pitout JDD, et al. Multiplex PCR Analysis for Rapid Detection of Klebsiella pneumoniae Carbapenem-Resistant (Sequence Type 258 [ST258] and ST11) and Hypervirulent (ST23, ST65, ST86, and ST375) Strains. J Clin Microbiol. 2018;56(9):e00731-18.

10.1128/JCM.00731-1829925644PMC6113471
15

Chiarelli A, Cabanel N, Rosinski-Chupin I, Zongo PD, Naas T, Bonnin RA, et al. Diversity of mucoid to non-mucoid switch among carbapenemase-producing Klebsiella pneumoniae. BMC Microbiol. 2020;20(1):325.

10.1186/s12866-020-02007-y33109078PMC7590720
16

Proctor RA, von Eiff C, Kahl BC, Becker K, McNamara P, Herrmann M, et al. Small colony variants: a pathogenic form of bacteria that facilitates persistent and recurrent infections. Nat Rev Microbiol. 2006;4(4):295–305.

10.1038/nrmicro1384
17

Tuchscherr L, Medina E, Hussain M, Völker W, Heitmann V, Niemann S, et al. Staphylococcus aureus phenotype switching: an effective bacterial strategy to escape host immune response and establish a chronic infection. EMBO Mol Med. 2011;3(3):129–141.

10.1002/emmm.20100011521268281PMC3395110
18

Song S, Yang S, Zheng R, Yin D, Cao Y, Wang Y, et al. Adaptive evolution of carbapenem-resistant hypervirulent Klebsiella pneumoniae in the urinary tract of a single patient. Proc Natl Acad Sci U S A. 2024;121(35):e2400446121.

10.1073/pnas.240044612139150777PMC11363291
19

Bain W, Ahn B, Peñaloza HF, McElheny CL, Tolman N, van der Geest R, et al. In Vivo Evolution of a Klebsiella pneumoniae Capsule Defect With wcaJ Mutation Promotes Complement-Mediated Opsonophagocytosis During Recurrent Infection. J Infect Dis. 2024;230(1):209–220.

10.1093/infdis/jiae00339052750PMC11272070
20

Fang CT, Yi WC, Shun CT, Tsai SF. DNA adenine methylation modulates pathogenicity of Klebsiella pneumoniae genotype K1. J Microbiol Immunol Infect. 2017;50(4):471–477.

10.1016/j.jmii.2015.08.022
21

Fu J, Zhang J, Yang L, Ding N, Yue L, Zhang X, et al. Precision Methylome and In Vivo Methylation Kinetics Characterization of Klebsiella pneumoniae. Genomics Proteomics Bioinformatics. 2022;20(2):418–434.

10.1016/j.gpb.2021.04.00234214662PMC9684165
22

Ghosh D, Pal A, Mohapatra S, Raj S, Vivekanandan P. Distinct epigenetic signatures of classical and hypervirulent Klebsiella pneumoniae. mSphere. 2024;9(1):e0046423.

10.1128/msphere.00464-2338112443PMC10826340
23

Panjaitan NSD, Horng YT, Chien CC, Yang HC, You RI, Soo PC, et al. The PTS Components in Klebsiella pneumoniae Affect Bacterial Capsular Polysaccharide Production and Macrophage Phagocytosis Resistance. Microorganisms. 2021;9(2):335.

10.3390/microorganisms902033533567595PMC7914778
24

Park S, Lee H, Shin D, Ko KS. Change of Hypermucoviscosity in the Development of Tigecycline Resistance in Hypervirulent Klebsiella pneumoniae Sequence Type 23 Strains. Microorganisms. 2020;8(10):1562.

10.3390/microorganisms810156233050506PMC7601201
25

Choi MJ, Ko KS. Loss of hypermucoviscosity and increased fitness cost in colistin-resistant Klebsiella pneumoniae sequence type 23 strains. Antimicrob Agents Chemother. 2015;59(11):6763–6773.

10.1128/AAC.00952-1526282408PMC4604379
26

Huang X, Li X, An H, Wang J, Ding M, Wang L, et al. Capsule type defines the capability of Klebsiella pneumoniae in evading Kupffer cell capture in the liver. PLoS Pathog. 2022;18(8):e1010693.

10.1371/journal.ppat.101069335914009PMC9342791
27

Mike LA, Stark AJ, Forsyth VS, Vornhagen J, Smith SN, Bachman MA, et al. A systematic analysis of hypermucoviscosity and capsule reveals distinct and overlapping genes that impact Klebsiella pneumoniae fitness. PLoS Pathog. 2021;17(3):e1009376.

10.1371/journal.ppat.100937633720976PMC7993769
28

Xu Q, Yang X, Chan EWC, Chen S. The hypermucoviscosity of hypervirulent K. pneumoniae confers the ability to evade neutrophil-mediated phagocytosis. Virulence. 2021;12(1):2050–2059.

10.1080/21505594.2021.196010134339346PMC8331041
Information
  • Publisher :The Korean Society for Microbiology and The Korean Society of Virology
  • Publisher(Ko) :대한미생물학회‧대한바이러스학회
  • Journal Title :JOURNAL OF BACTERIOLOGY AND VIROLOGY
  • Volume : 55
  • No :4
  • Pages :327-340
  • Received Date : 2025-11-04
  • Revised Date : 2025-11-21
  • Accepted Date : 2025-12-26