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Review Article

The Role of Skin Microbiome in Human Health and Diseases
Aimon Khan12
,
Young-Sang Koh123*
1Department of Microbiology and Immunology, College of Medicine, Jeju National University, Jeju 63243, Republic of Korea
2Department of Biomedicine and Drug Development, Graduate School, Jeju National University, Jeju 63243, Republic of Korea
3Jeju Research Center for Natural Medicine, Core Research Institute, Jeju National University, Jeju 63243, Republic of Korea
*yskoh7@jejunu.ac.kr
30 September 2024. pp. 191-202
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Abstract

A diverse community of microorganisms that comprise the human skin microbiome affects skin health and overall well-being. Bacteria, archaea, fungi, and viruses reside on the skin surface and interact closely with the host system. Advancements in sequencing technologies and bioinformatics have greatly improved our understanding of the composition, function, and changes in skin microbiome during health and disease development. Skin microbiome maintains skin barrier function by regulating immunity and protecting against pathogens. Dysbiosis (imbalances in these communities) is associated with skin conditions such as atopic dermatitis, acne vulgaris, and psoriasis. Furthermore, growing evidence suggests that skin microbiome can influence health through connections, such as the gut-skin axis. Age, sex, personal hygiene habits, and environmental exposure can affect skin microbiome diversity. Treatment approaches that target the microbiome by using probiotics, prebiotics, or microbiome transplantation can manage skin diseases and improve skin health. However, when developing effective personalized treatments, challenges persist in establishing the cause-and-effect relationships between skin microbiome changes and specific diseases. Future long-term studies should be conducted using omics techniques to understand better the mechanisms by which certain microbes function and interact with the body. Delving further into skin microbiome creates opportunities for creating tools, treatments, and prevention methods in dermatology and other fields.

Keywords
Skin microbiome
Health
Diseases
Therapeutic modulation
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Information
  • Publisher :The Korean Society for Microbiology and The Korean Society of Virology
  • Publisher(Ko) :대한미생물학회‧대한바이러스학회
  • Journal Title :JOURNAL OF BACTERIOLOGY AND VIROLOGY
  • Volume : 54
  • No :3
  • Pages :191-202
  • Received Date : 2024-08-02
  • Revised Date : 2024-08-20
  • Accepted Date : 2024-08-26
  • DOI :https://doi.org/10.4167/jbv.2024.54.3.191
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