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2024 Vol.54, Issue 2 Preview Page

Original Article

Prevalence, Antimicrobial Susceptibility, and Carbapenem Resistance of Non-baumannii Acinetobacter Species in Three Korean Hospitals
Shukho Kim13
,
Md Shohel Rana1
,
Bokyung Kim1
,
Seong-Yeob Kim1
,
Nayeong Kim1
,
Da Eun Lee2
,
Je Chul Lee123*
1Department of Microbiology, School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea
2Kyungpook National University Hospital National Culture Collection for Pathogens (KNUH-NCCP), Kyungpook National University Hospital, Daegu 41944, Republic of Korea
3Untreatable Infectious Disease Institute, Kyungpook National University, Daegu 41944, Republic of Korea
*leejc@knu.ac.kr
30 June 2024. pp. 134-142
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Abstract

Non-baumannii Acinetobacter species are increasingly prevalent as opportunistic pathogens in the hospitals worldwide. However, the current information of epidemiology and antimicrobial susceptibility of non-baumannii Acinetobacter species is limited in Korea. This study investigated the species distribution, antimicrobial susceptibility, and carbapenem resistance mechanisms of 65 non- baumannii Acinetobacter isolates from three Korean hospitals during 2017 to 2020. Sixteen different Acinetobacter species were identified. Among them, A. ursingii (n = 16), A. junii (n = 11), and A. nosocomialis (n = 9) were prevalent, accounting for 55.4% of the isolates. A half (50.8%) of non-baumannii Acinetobacter isolates were susceptible to all antimicrobial agents tested. Non-baumannii Acinetobacter isolates exhibited the highest resistance rate to piperacillin (26.2%), whereas no isolates were resistant to minocycline and tigecycline. Seven isolates were resistant to carbapenems by the production of carbapenemases. Ambler class B (blaNDM-1 and blaVIM-2) and class D carbapenemase genes (blaOXA-23, blaOXA-58, blaOXA-211, and blaOXA-213) were detected. Three isolates carried two or more carbapenemase genes. One A. calcoaceticus isolate co-carried blaVOXA-58, blaOXA-213, and blaNDM-1. In conclusion, this study provides new insights into antimicrobial susceptibility and carbapenem resistance mechanisms of Korean non-baumannii Acinetobacter species. The spread of carbapenem resistance genes should be carefully monitored among non-baumannii Acinetobacter species.

Keywords
Non-baumannii Acinetobacter
Antimicrobial susceptibility
Carbapenem resistance
Metallo-β-lactamase
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Information
  • Publisher :The Korean Society for Microbiology and The Korean Society of Virology
  • Publisher(Ko) :대한미생물학회‧대한바이러스학회
  • Journal Title :JOURNAL OF BACTERIOLOGY AND VIROLOGY
  • Volume : 54
  • No :2
  • Pages :134-142
  • Received Date : 2024-05-01
  • Revised Date : 2024-05-23
  • Accepted Date : 2024-05-27
  • DOI :https://doi.org/10.4167/jbv.2024.54.2.134
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